临床百问丨银屑病治疗要等多久?他卡西醇起效时间+效果全解析!

临床百问丨银屑病治疗要等多久?他卡西醇起效时间+效果全解析!

² 可用于全身性斑块状银屑病,疗效与倍他米松无显著性差异

² 可用于头面部银屑病:卡西醇治疗头面部银屑病疗效优于卡泊三醇

² 可用于甲银屑病:治疗6个月, NAPSI评分较基线降低78%

l 他卡西醇治疗银屑病长效安全、复发率低

² 他卡西醇治疗银屑病长效安全:治疗18个月,PASI中位数从9.5下降到3.25;血钙水平保持不变、不良反应发生率低、刺激性小

² 他卡西醇治疗银屑病复发率低:他卡西醇与激素序贯治疗6周,随访3个月,复发率仅为10%

参考文献:

1. P C Van de Kerkhof,et al.Tacalcitol ointment in the treatment of psoriasis vulgaris: a multicentre, pla

-cebo-controlled, double-blind study on efficacy and safety[J]Br J Dermatol.1996 Nov;135(5):758-65.

2. Dermatology (2006) 213 (4): 319–326.

3. Scarpa C,et al.Tacalcitol ointment is an efficacious and well tolerated treatment for psoriasis. J Eur

Acad Dermatol Venereol.6 (1996)142-146.

4. Prof Dr A Langner;W Staçpór;M Ambroziak.Vitamin D3 metabolites and analogues in the treatment

of scalp psoriasis[J]Journal of Dermatological TreatmentVolume 9, Issue , 2009, PP.

5. M Sánchez Regaña,at.Nail psoriasis: a combined treatment with 8% clobetasol nail lacquer and taca

-lcitol ointment.JEADV 2008, 22, 963–969.

6. HjulerKF,et al.Localization of treatment-resistant areas in patients with psoriasis on biologics[J].The

British journal of dermatology. Volume 181 , Issue 2 . 2019. PP 332-337.

7. Prof Dr A Langner;W Staçpór;M Ambroziak.Vitamin D3 metabolites and analogues in the treatment of

scalp psoriasis[J]Journal of Dermatological TreatmentVolume 9, Issue , 2009, PP.

8. Prignano Francesca,et ai.Clinical evaluation of topical tacalcitol efficacy in extending the remission

period between nb-UVB phototherapy cycles in psoriatic patientsVolume 80, Issue 1,2009,PP 51-6.

9. Lambert J,Trompke C.Long-term efficacy and safety of tacalcitol ointment in patients with chronic

plaque psoriasis[J],British Journal of Dermatology. 2002; 146: 414-422.

10. C. Queille-Roussel,et al.The safety of calcitriol 3 mugg ointment. Evaluation of cutaneous contact

sensitization, cumulative irritancy, photoallergic contact sensitization and phototoxicity[J]European

Journal of Dermatology. Vol. 11, Issue 3, May - June 2001: 219-24.

11.邵俊,胡彬.他卡西醇联合卤米松序贯治疗斑块型银屑病的临床疗效[J].浙江中医药大学学报,2013,

37(12):1409-1411.

12.中华医学会皮肤性病学分会银屑病专业委员会. 中国银屑病诊疗指南(2023版)[J].中华皮肤科杂

志,2023, 56(7):573-625.

13.卡泊三醇说明书.返回搜狐,查看更多

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